The Harder The Material The Harder It Is To Cut Holes In It.
For metal you could use a torch, but what if you didn't want any discoloration and no rough edges. And you don't have the fancy computer controlled plasma cutters some big shops have. The answer is probably going to be a hole saw.
This video discusses the tricks you need to know about cutting holes in metal safely with a hole saw. Watch and learn.
If you need to drill a hole in stainless steel, say a hole in a kitchen sink, there is a better way.
Click here to check out this better way.